All posts by erin

Zoos and the Protection of Rare Animals

Conservation, Headline Makers, Zoology

This semester as an elective I am taking another course in the zoology department (the first being Patricia McConnell’s Human and Animal Relationships last semester). In Zack Peery’s Extinction of Species we have been discussing the role that institutions like zoos play in helping to preserve and ensure the survival of rare species. Often we think of zoos in terms of their enjoyment factor for humans or conversely the lack of enjoyment (we think) that animals have being caged. I’ve visited the zoo here in Madison and had a nice time being there with my family, but I was definitely thinking about the care and condition of the animals. Now, I thought all of the animals in the zoo I visited looked healthy and happy, but it did get me thinking overall about how important zoos are for the care and conservation of animals, particularly those that are rare or in need of special healthcare.

Zoos play an important role in conservation efforts, because the good ones provide animals with a safe place to live that is protected from outside threats (predators, pollution, loss of habitat, etc.), in addition to access to veterinarians. I was reminded of this fact when I saw the story of Manukura, a rare white kiwi being covered by the BBC. Not that we really needed further proof that a good cute animal story is going to make it into the news, but I wanted to mention the kiwi story because I think it is a good example of the public rallying behind a very charismatic animal, and a zoos effort to save and protect it.

Manukura. Source: Zooborns

A kiwi is a flightless bird that lives only in New Zealand, and is similar in size to a chicken. There are five species of kiwi, which are all endangered. Kiwis are typically brown or tan in color, but as a result of a naturally occurring genetic mutation Manukura was born white (note that this isn’t the same as being an albino). Manukura was living in Pukaha Mount Bruce National Wildlife Center when rangers noticed that the six-month-old bird wasn’t eating. Veterinarians at New Zealand’s Wellington Zoo were called in to examine the bird and found that two large stones were obstructing its intestines.

Manukura was able to pass one of the stones naturally, but the other had to be taken out by a urology specialist from Wellington Hospital who broke the stone up with a laser and then removed the pieces with an endoscope. According to the Wildlife Center, the procedure was comparable to the removal of kidney or gall stones in a human. The bird is doing well following her procedure, much to the joy of her Facebook followers who were able to follow her progress throughout the ordeal.

I think that this story is a great case study for a lot of the topics that we’ve been discussing in my zoology class. It shows a viable option (the creation of wildlife refuges) for the conservation of a species, how a the public can rally behind a species that is particularly like able and important (the kiwi is a national symbol of New Zealand), how zoos can provide access to resources necessary to save an animal, and how communication with the public (particularly through social media) is an important part of conservation and animal protection efforts.

Covering The Wisconsin Science Festival

Grad School, Interviewing, Public Perceptions, Videos

In my integrated media and storytelling class this semester our first project was to cover an event using pictures and audio, and combine it into a slideshow. I chose the first Wisconsin Science Festival at the Wisconsin Institutes for Discovery.

I had some upload problems trying to convert from a SoundSlides project into something uploadable but I finally got there. I edited the pictures in Photoshop and iPhoto, and edited the audio using Audacity. I lost a lot of photo quality in the conversion, but please watch and let me know what you think. This was my first foray into multi-media so any feedback would be much appreciated.

Science For Six-Year-Olds: Sugar Maple Trees

First Grade, Science For Six Year Olds

This post is part of a recurring segment here on Science Decoded where I blog for the first graders at Lincoln-Hubbard Elementary School about the various units in their science program.

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800px-Acer_saccharum_leavesHello First Graders!

I hear you are studying trees in your science class, and I wanted to share with you some of the special aspects of a certain type of tree: The Sugar Maple.

The Sugar Maple (scientific name: Acer saccharum) is a deciduous tree. Deciduous means that its leaves change color and fall off during the Fall. A Sugar Maple tree can grow as tall as 82-115 feet, but it takes a long time to get that big. After ten years (thats older than all of you!) a Sugar Maple tree will usually only be about 16 feet tall. The leaves on a Sugar Maple tree are usually around 7-8 inches long, and have five lobes. Take a look at the picture of the leaves, do they look familiar? Do any of you have Sugar Maple trees in your backyard? What about at the school?

Super Maple Tree Range
Super Maple Tree Range

The Sugar Maple is a tree that can be found in hardwood forests throughout northeastern North America, which includes Canada and the United States. Take a look at this map, the green part is where Sugar Maple trees grow. Do you see New Jersey? How about Wisconsin? Sugar Maple trees grow in New Jersey where you are, and Wisconsin where I am.

Sugar Maples are very important because they are able to grow really well in shady areas and also provide habitat (places to live) for animals in the forest. This species of tree isn’t rare or endangered, but it is a special part of these forest ecosystems. An ecosystem is a biological (natural) area made of all the living and non-living parts of the environment, this means all the plants (like Sugar Maples!) animals, water, sunlight, and even soil. All of these things need to be healthy to make the environment strong. In addition to being important for the forest ecosystem, Sugar Maples also have a special ability. These trees can also be useful for people to make products like Maple Syrup.

Sugar Maple trees have a sugary sap inside them that people can harvest in the Spring by making a hole in the trunk and collecting the sap that runs out. When the sap is heated, some of the water evaporates, leaving behind syrup. Here is an example of what collecting the sap looks like, it is being drained into those buckets attached to the trees

Now I have a surprise for you! We have a special Farmer’s Market here in Wisconsin, that is one of the biggest Farmer’s Markets in the country. Have any of you ever gone to the Farmer’s Market where you live? It is a place where local farmer’s bring their fruits, vegetables, and other products to sell. Here in Wisconsin you can buy some of the products people make from Sugar Maple trees at the Farmer’s Market.

I filled up a little package for you with information about the Wisconsin Farmer’s Market, some Sugar Maple products, and even a little surprise from the University of Wisconsin’s mascot Bucky Badger. I hope you like it! Let me know if you have any questions about Sugar Maple trees!

BioTechnology Patents: Kyoto Claims iPSCs

BioTechnology, Headline Makers, Science Policy

Can you patent a gene? What about a cell? When it comes to the components of life, and more importantly the ideas, processes, and procedures developed to manipulate these components, what belongs to who? This is a question that is certainly going to be fought out from the patent office to the courts as more and more biomedical discoveries are made.

iPS cell cluster. Source: NINDS.NIH.gov

One discovery that has recently (meaning August) been in the news for patent applications is Shinya Yamanaka’s 2006 discovery of the combination of genes that can be used to reprogram adult cells to a pluripotent (capable of becoming any kind of cell) state. With these induced pluripotent stem cells (iPSCs) lies the hope of a suitable answer to the debate over the need for pluripotency, but the social and religious controversy over using human embryonic stem cells (which are naturally pluripotent).

While working at Kyoto University in Japan, Yamanaka found that the genes Oct3/4, SOX2, c-Myc, and Klf4 are key to pluripotency. This discovery led to the creation of the first iPSCs. Now, five years and millions of dollars in research later, Kyoto University has obtained patent rights for iPSC technology in six nations and two regions, including the United States. This development leads me back to the question I started with, can you patent a gene? What about the ideas or technology based on those genes? Apparently, you can because Kyoto University has. But, I’m still quite curious about how this will play out functionally.

The discovery of iPSCs was huge news. It prompted researchers around the world to start working with iPSCs, many of whom have subsequently made their own discoveries, published their own research in peer reviewed journals (just type pluripotent into PubMed you’ll see what I mean), and expanded greatly on the existing body of knowledge about pluripotency. This includes the discovery of numerous variations of gene combinations that play a role in pluripotency. So if Kyoto University owns the original idea, do they own everyone elses’ work too? According to university spokeswoman Akemi Nakamura, they do. Nakamura says the patent broadly covers variations of the technology developed since 2006 in laboratories around the world.

In a press release the University stated:

“The US patent covers combinations of nuclear reprogramming family factors comprising an Oct family gene, a Klf family gene, and Myc family gene; or an Oct family gene, a Klf family gene, and a cytokine. This means that if companies use a combination of the nuclear reprogramming genes and generate iPSCs, regardless of the kinds of vectors, they need to get the patent license.”

So if Kyoto University owns the right to the genes, and the subsequent developments based on the genes what does that mean for iPSC researchers? Right now the university says it will not restrict research using iPSCs for non-profit purposes, so that would mean research whose end goal isn’t the marketing of a specific product based on iPSC technology will be able to continue unhindered. Companies that want to work with iPSCs for profit may have to pay a licensing fee. Although, it is important to note that not all iPSC research is based on these genes – there are other combinations of genes that can induce pluripotency, and thus lines of inquiry in this field that don’t belong to Kyoto University.

How important all of this will be, and when it will be important is a bit murky. iPSCs have their own problems (namely, teratomas) and haven’t yet been developed for widespread, let alone commercial, use. Though, with all of the resources being poured into iPSC development, I think it is only a matter of time until the cells become more useable. This is a story to watch, it is hard to say exactly how it will work out but it is sure to be an issue that continues to come up.

As for me, I’m not really sure where I fall on this issue. I can see the need to protect intellectual achievements and make sure that the wrong people don’t profit, but at the same time I wish it wasn’t necessary and open inquiries could be pursued without people having to worry about others cashing in on their ideas. If only it could be that way.

Book Review: Devices & Desires

Book Review, Good Writing, Grad School, Science History,

I thought it was amusing that the first condoms in history were made from the casings of animal intestines. Yet, when I tried to share this information I was met with the typical head shaking, and entreaties to find different reading material characteristic of me sharing new found knowledge with friends. In my post about Mary Roach’s Stiff, I mentioned how my friends don’t find the interesting tidbits I gleaned about cadavers to be proper cocktail conversation. Well, the same goes for all the interesting tidbits I gathered from reading Andrea Tone’s Devices & Desires.

I am taking a history of science course this semester on the history of women and health in America. As a grad student in an undergrad class, I have to complete extra work to make the requirements. One of the extra assignments was to read and discuss Devices & Desires: A History of Contraceptives in America with the other grad student and the professor. I am a fish out of water in this class, having no background whatsoever in women’s issues (aside from, you know being a woman myself), and while I was aware of the timeline for the development of contraceptives there was a lot about them I didn’t know. Thus my excited, and apparently gross, interest in what I learned from the book.

DandDDevices & Desires can be broken roughly into three sections: condoms, the pill, and intrauterine devices (IUDs). The section about condoms was by far the most interesting and engaging. My professor (Karen Walloch) suggested that perhaps this was the section that Tone researched for her thesis, and while that is just speculation it does seem to be the part of the book that the writer was most invested in. Fun fact: when scientists first developed a way for rubber to be shaped and thus used as condoms, companies that today we associate with tires (Firestone, BF Goodrich, Goodyear) all dabbled in condoms.

My favorite chapters in the book dealt with the military’s stance on condoms during WWI, and how they eventually had to cave and endorse them because the health care cost of venereal diseases was through the roof. The book had a few different advertisements and propaganda posters for servicemen urging them to stay away from women that I found highly amusing. Apparently just say no, and taking the moral high ground are no match for a dame in a dress.

After the condom chapters the book tackles the birth control pill. While I found the information interesting, I felt like it fell a little flat. For such a controversial topic, that had such a drastic impact on women’s lives I think Tone could have infused the writing with more personality. It just wasn’t as colorful as the condom chapters. As a science writer, I did really appreciate the description of the research process that went into making synthetic hormones and how these were tested. The initial testing on the pill was done in Puerto Rico, because the researchers/financiers thought there wouldn’t be as much controversy and public push back. They were very wrong. But, if you aren’t interested in the scientific process, I feel like these chapters might drag on for you as a reader.

From the pill, the book moves on to the IUD. Tone focuses on a particular IUD, the Dalkon Shield. I was really shocked by this part of the book. Shocked, and really kind of outraged that I hadn’t heard about this health scandal. In the 1970’s the Dalkon Shield was the cause of more than 200,000 lawsuits due to a high percentage of severe injury among its users. The design of this IUD made it a ticking time bomb that women were sticking into their bodies. Infections (and subsequent Pelvic Inflammatory Disease) caused by the materials used in the device caused severe damage to women’s reproductive systems (even sterility), the device could also perforate the uterine wall, and women who did get pregnant while wearing the device often had children born with severe birth defects.

Lawsuits against the A.H. Robbins Corporation (who marketed the Dalkon Shield) won millions of dollars in damages for women and families that had been affected. The real tragedy in the Dalkon Shield scandal is that the company was well aware of the device’s problems. Internal documents and studies proved that the company knew the device was dangerous, and marketed it anyway. As a result of the scandal, in 1976 the Medical Device Amendments to the Food, Drug, and Cosmetic Act mandated the U.S. Food and Drug Administration for the first to time test and approve of medical devices.

It is important to note that the major flaw in the Dalkon Shield: a porous, multifilament string that was basically a highway for bacteria straight up into the uterus, isn’t a part of IUDs currently on the market. I know several people who use IUDs and am relieved to know that the devices have been improved since they first debuted on the contraceptive scene. However, the Dalkon Shield story really made me stop and think about the human cost of not only contraceptive devices, but all new medical breakthroughs.

As much as I learned from and was moved by reading the chapters about IUDs in Tone’s book, these chapters left me wanting more. I felt like the book ended very abruptly, and that there was still a lot that could have been said about the topic. My professor pointed out that when you are writing a book like this, you have to choose a place to stop, otherwise you could just go on and on. I understand that, but I think the book could have ended more smoothly.

Overall, I thought Devices & Desires was a great read and I learned a lot from it that I hadn’t been aware of otherwise. The book was a little disjointed in parts, and you have to be invested in seeing it through (and apparently not squeamish) but if you come from an uninformed background like mine, I can almost guarantee you’ll learn something new.